A more reliable diagnosis of preterm birth is one of the biggest unsolved problems in modern obstetrics. Pregnolia's approach is unique and ground-breaking: We work for a simple, reliable and easy to use diagnostic device to fight the burden of preterm birth.

 


Thanks to co-funding from the European Union we can develop a cost-effective, worldwide scalable solution.
Our vision is a new preterm birth screening test which will bring relief to doctors, mothers and new-born worldwide.

sTUDIes

Below a list of scientific publications regarding the Pregnolia System and its prototypes

  • Aspiration technique-based device is more reliable in cervical stiffness assessment than digital palpation
    The Pregnolia System revamps a classical gynaecological assessment, cervical palpation. Cervical stiffness measured with our device is considerably more reliable than digital palpation.
    Check out the video.

  • Aspiration technique-based device is more reliable in cervical stiffness assessment than digital palpation
    The Pregnolia System revamps a classical gynaecological assessment, cervical palpation. Cervical stiffness measured with our device is considerably more reliable than digital palpation.
    Check out the video.

  • Objective assessment of cervical stiffness after administration of misoprostol for intrauterine contraceptive insertion
    The influence of misoprostol on cervical stiffness is assessed via measuring the stiffness in misoprostol users prior to intrauterine contraceptives insertion and at follow-up consultation with the Pregnolia System.

  • Objective assessment of cervical stiffness after administration of misoprostol for intrauterine contraceptive insertion
    The influence of misoprostol on cervical stiffness is assessed via measuring the stiffness in misoprostol users prior to intrauterine contraceptives insertion and at follow-up consultation with the Pregnolia System.

  • Cervical softening occurs early in pregnancy: characterization of cervical stiffness in 100 healthy women using the aspiration technique
    The Pregnolia System measures cervical stiffness: the device was used in 50 non-pregnant and 50 pregnant women to measure cervical stiffness in normal pregnancies.

  • Cervical softening occurs early in pregnancy: characterization of cervical stiffness in 100 healthy women using the aspiration technique
    The Pregnolia System measures cervical stiffness: the device was used in 50 non-pregnant and 50 pregnant women to measure cervical stiffness in normal pregnancies.

The Pregnolia System is currently used in the following clinical studies

  • SoftCervix
    The study aims to demonstrate that biomechanical data (cervical stiffness) might complement morphological data (cervical length) to improve prediction of preterm delivery. Cervical stiffness with the Pregnolia System is measured at mid-pregnancy.

  • SoftCervix
    The study aims to demonstrate that biomechanical data (cervical stiffness) might complement morphological data (cervical length) to improve prediction of preterm delivery. Cervical stiffness with the Pregnolia System is measured at mid-pregnancy.

  • ATOPS
    This trial quantifies the mechanical environment of pregnancies complicated by a short cervix and randomized to receive a pessary via ultrasound imaging and cervical stiffness measurement.

  • ATOPS
    This trial quantifies the mechanical environment of pregnancies complicated by a short cervix and randomized to receive a pessary via ultrasound imaging and cervical stiffness measurement.

  • Cervical stiffness measurement in cervical insufficiency
    Will women for whom a cerclage is indicated have cervical stiffness lower than normal controls? This study is investigating this question via using the Pregnolia System.

  • Cervical stiffness measurement in cervical insufficiency
    Will women for whom a cerclage is indicated have cervical stiffness lower than normal controls? This study is investigating this question via using the Pregnolia System.

References

Feedback from first established doctor using the Pregnolia measurement device:


«The diagnosis of preterm birth in the low risk population, allowing timely initiation of therapy, is THE unsolved problem in modern obstetrics. We want to offer the Pregnolia System to our patients in order to know who is at risk, and for the best care possible.»


Dr. Bettina von Seefried, Owner of Gyn Health GmbH Zürich

Watch the video presentation of Dr. von Seefried.

EU Horizon information

Pregnolia has been awarded a SME Instrument Phase 2 Grant of € 1.28 million. The grant is used to improve the manufacturability of the diagnostic device for the preterm birth risk assessment and to perform activities towards commercial readiness.

Read the interview of Sabrina Badir.

The project runs from September 2019 to August 2021.

Project details can be found here.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 873553.

«A diagnostic medical device determining the risk of premature birth - Pregnolia»

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